翻訳と辞書 Words near each other ・ Loop 12 (DART station) ・ Loop algebra ・ Loop antenna ・ Loop around ・ Loop Ash Records ・ LOOP Barcelona ・ Loop bin duplicator ・ Loop braid group ・ Loop counter ・ Loop Creek ・ Loop Creek (West Virginia) ・ Loop Current ・ Loop dependence analysis ・ Loop device ・ Loop di Love ・ Loop diuretic ・ Loop electrical excision procedure ・ Loop entropy ・ LOOP Filmworks ・ Loop fission ・ Loop fusion ・ Loop gain ・ Loop group ・ Loop Guru ・ Loop Halt railway station ・ Loop Head ・ Loop heat pipe ・ Loop I Bubble ・ Loop Independent School District ・ Loop integral Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Loop diuretic ： ウィキペディア英語版 Loop diuretic Loop diuretics are diuretics that act at the ascending loop of Henle in the kidney. They are primarily used in medicine to treat hypertension and edema often due to congestive heart failure or renal insufficiency. While thiazide diuretics are more effective in patients with normal kidney function, loop diuretics are more effective in patients with impaired kidney function. ==Mechanism of action== Loop diuretics act on the Na+-K+-2Cl− symporter (cotransporter) in the thick ascending limb of the loop of Henle to inhibit sodium, chloride and potassium reabsorption. This is achieved by competing for the Cl− binding site. Because magnesium and calcium reabsorption in the thick ascending limb is dependent on the positive lumen voltage gradient set up by potassium recycling through renal outer medullary potassium channel, loop diuretics also inhibit their reabsorption. By disrupting the reabsorption of these ions, loop diuretics prevent the generation of a hypertonic renal medulla. Without such a concentrated medulla, water has less of an osmotic driving force to leave the collecting duct system, ultimately resulting in increased urine production. Loop diuretics cause a decrease in the renal blood flow by this mechanism. This diuresis leaves less water to be reabsorbed into the blood, resulting in a decrease in blood volume. A secondary effect of loop diuretics is to increase the production of prostaglandins, which results in vasodilation and increased blood supply to the kidney. NSAIDs block the COX pathway that synthesizes prostaglandins, so NSAIDs can reduce the efficacy of loop diuretics. The collective effects of decreased blood volume and vasodilation decrease blood pressure and ameliorate edema. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Loop diuretic」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.